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Editorial Board
Chair
PR Shepherd - Auckland

Vice Chair, The Americas
G Salvesen - La Jolla, CA

Vice Chair, Asia-Pacific
T Xu - Beijing

Vice Chair, Europe
DR Alessi - Dundee

Vice Chair, Reviews
A Toker - Boston, MA

Deputy Chairs
M Blatt - Glasgow
D Carling - London
JF Cáceres - Edinburgh
L Goodyear - Boston, MA
D Hoekstra - Groningen
S Huber - Urbana, IL
J Ladbury - Houston, TX
M Lemmon - Philadelphia, PA
C MacKintosh - Dundee
M Murphy - Cambridge
S Roberts - Buffalo, NY
M Schwartz - New Haven, CT
D Tosh - Bath
D van Aalten - Dundee
B Vanhaesebroeck - London
HM Wallace - Aberdeen
MF White - St Andrews
Editors in China
XiaoFeng Cao - Beijing
Ye-Guang Chen - Beijing
Randy Poon - Hong Kong
Donghai Wu - Guangzhou
Aimin Xu - Hong Kong
Hong-Wei Xue - Shanghai

Editorial Advisors in China
Yan Chen - Shanghai
Jianping Ding - Shanghai
Youfei Guan - Beijing
Depei Liu - Beijing
Guoliang Xu - Shanghai
Zhuohua Zhang - Hunan

Spotlight on China

Reviews
How protein kinases co-ordinate mitosis in animal cells
H. T. Ma and R. Y. C. Poon
(2011) 435, 17‑31
Published on the Internet 15 March 2011, doi:10.1042/BJ20100284
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Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling
X. Yan and Y.‑G. Chen
(2011) 434, 1‑10
Published on the Internet 27 January 2011, doi:10.1042/BJ20101827
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Regulation of TGF-β signalling by protein phosphatases
T. Liu and X.‑H. Feng
(2010) 430, 191‑198
Published on the Internet 13 August 2010, doi:10.1042/BJ20100427
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The author has paid for access to this article to be freely availableFunction and regulation of phospholipid signalling in plants
H.‑W. Xue, X. Chen and Y. Mei
(2009) 421, 145‑156
Published on the Internet 26 June 2009, doi:10.1042/BJ20090300
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Post-translational modifications of adiponectin: mechanisms and functional implications
Y. Wang, K.S.L. Lam, M.-h. Yau and A. Xu
(2008) 409, 623–633
Published on the Internet 15 January 2008, doi:10.1042/BJ20071492
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Research papers
Microsomal prostaglandin E synthase-1 exhibits one-third-of-the-sites reactivity
Shan He, Yiran Wu, Daqi Yu and Luhua Lai..........440, 13‑21
Published as BJ Immediate Publication 29 July 2011, doi:10.1042/BJ20110977
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Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism
Bing Wang, Yingjie Peng, Tianlong Zhang and Jianping Ding..........439, 215‑225
Published as BJ Immediate Publication 28 June 2011, doi:10.1042/BJ20110753
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CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes
Xi Ma, Heyu Zhang, Lan Yuan, Hao Jing, Phil Thacker and Defa Li..........439, 27‑38
Published as BJ Immediate Publication 28 June 2011, doi:10.1042/BJ20101475
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Active-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidases
Tian Liu, Haitao Zhang, Fengyi Liu, Lei Chen, Xu Shen and Qing Yang..........438, 467‑474
Published as BJ Immediate Publication 21 June 2011, doi:10.1042/BJ20110390
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Interaction between bacterial outer membrane proteins and periplasmic quality control factors: a kinetic partitioning mechanism
Si Wu, Xi Ge, Zhixin Lv, Zeyong Zhi, Zengyi Chang and Xin Sheng Zhao..........438, 505‑511
Published as BJ Immediate Publication 14 June 2011, doi:10.1042/BJ20110264
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ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
Houkai Li, Qingshu Meng, Fei Xiao, Shanghai Chen, Ying Du, Junjie Yu, Chunxia Wang and Feifan Guo..........438, 283‑289
Published as BJ Immediate Publication 7 June 2011, doi:10.1042/BJ20110263
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Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway
Di‑xian Luo, Mei C. Huang, Jun Ma, Zachary Gao, Duan‑fang Liao and Deliang Cao..........438, 71‑80
Published as BJ Immediate Publication 18 May 2011, doi:10.1042/BJ20110111
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Arachidonic acid modulates Na+ currents by non-metabolic and metabolic pathways in rat cerebellar granule cells
Yan‑Jia Fang, Meng‑Hua Zhou, Xiao‑Fei Gao, Hua Gu and Yan‑Ai Mei..........438, 203‑215
Published as BJ Immediate Publication 12 May 2011, doi:10.1042/BJ20110569
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Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src
Xiu‑Qing Yao, Xiao‑Xue Zhang, Yang‑Yang Yin, Bin Liu, Dan‑Ju Luo, Dan Liu, Ning‑Ning Chen, Zhong‑Fei Ni, Xiong Wang, Qun Wang, Jian‑Zhi Wang and Gong‑Ping Liu..........437, 335‑344
Published as BJ Immediate Publication 9 May 2011, doi:10.1042/BJ20110347
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Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells
Ke‑Wen Zhao, Deepa Sikriwal, Xueyuan Dong, Peng Guo, Xiaodong Sun and Jin‑Tang Dong..........436, 323‑333
Published as BJ Immediate Publication 4 May 2011, doi:10.1042/BJ20101388
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GULP1 is a novel APP-interacting protein that alters APP processing
Candy Yan Hao, Michael S. Perkinton, William Wai‑Lun Chan, Ho Yin Edwin Chan, Christopher C. J. Miller and Kwok‑Fai Lau..........436, 631‑639
Published as BJ Immediate Publication 13 April 2011, doi:10.1042/BJ20110145
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Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway
Zhen‑Bo Song, Yong‑Li Bao, Yu Zhang, Xu‑Guang Mi, Ping Wu, Yin Wu, Chun‑Lei Yu, Ying Sun, Li‑Hua Zheng, Yan‑Xin Huang, Biao Liu and Yu‑Xin Li..........436, 457‑467
Published as BJ Immediate Publication 8 March 2011, doi:10.1042/BJ20101780
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Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin
Zhe Chen, Tong‑Jin Zhao, Jie Li, Yan‑Song Gao, Fan‑Guo Meng, Yong‑Bin Yan and Hai‑Meng Zhou..........436, 437‑445
Published as BJ Immediate Publication 22 March 2011, doi:10.1042/BJ20102007
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Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC
Yang Du, Wei‑Wei Shi, Yong‑Xing He, Yi‑Hu Yang, Cong‑Zhao Zhou and Yuxing Chen..........436, 283‑289
Published as BJ Immediate Publication 3 March 2011, doi:10.1042/BJ20102097
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Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling
Kai Song, Qin Li, Yong‑Bo Peng, Jie Li, Kan Ding, Li‑Juan Chen, Cheng‑Hao Shao, Li‑Jun Zhang and Ping Li..........436, 271‑282
Published as BJ Immediate Publication 29 March 2011, doi:10.1042/BJ20110297
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Solution structure of the Taf14 YEATS domain and its roles in cell growth of Saccharomyces cerevisiae
Wen Zhang, Jiahai Zhang, Xuecheng Zhang, Chao Xu and Xiaoming Tu..........436, 83‑90
Published as BJ Immediate Publication 28 February 2011, doi:10.1042/BJ20110004
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Autotransporter passenger domain secretion requires a hydrophobic cavity at the extracellular entrance of the β-domain pore
Y. Zhai, K. Zhang, Y. Huo, Y. Zhu, Q. Zhou, J. Lu, I. Black, X. Pang, A. W. Roszak, X. Zhang, N. W. Isaacs and F. Sun
(2011) 435, 577‑587
Published as BJ Immediate Publication 10 February 2011, doi:10.1042/BJ20101548
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Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase
X. Gao, K. Li, X. Hui, X. Kong, G. Sweeney, Y. Wang, A. Xu, M. Teng, P. Liu and D. Wu
(2011) 435, 723‑732
Published as BJ Immediate Publication 24 February 2011, doi:10.1042/BJ20101680
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HID-1 is a novel player in the regulation of neuropeptide sorting
Y. Yu, L. Wang, Y. Jiu, Y. Zhan, L. Liu, Z. Xia, E. Song, P. Xu and T. Xu
(2011) 434, 383‑390
Published as BJ Immediate Publication 21 January 2011, doi:10.1042/BJ20110027
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Flexibility of the Ure2 prion domain is important for amyloid fibril formation
Y. Yu, H.‑Y. Wang, M. Bai and S. Perrett
(2011) 434, 143‑151
Published as BJ Immediate Publication 23 November 2010, doi:10.1042/BJ20101895
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The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulation
L. Wang, L. Zhu and C.‑c. Wang
(2011) 434, 113‑121
Published as BJ Immediate Publication 23 November 2010, doi:10.1042/BJ20101357
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Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Nav1.6 in BmK I-induced neuronal hyperexcitability
H. He, Z. Liu, B. Dong, J. Zhou, H. Zhu and Y. Ji
(2010) 431, 289‑298
Published as BJ Immediate Publication 2 August 2010, doi:10.1042/BJ20100517
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Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690
X.‑Long Zhou, M. Tan, M. Wang, X. Chen and En‑Duo Wang
(2010) 430, 325‑333
Published as BJ Immediate Publication 18 June 2010, doi:10.1042/BJ20100474
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Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes
R. Wang, X. Kong, A. Cui, X. Liu, R. Xiang, Y. Yang, Y. Guan, F. Fang and Y. Chang
(2010) 430, 245‑254
Published as BJ Immediate Publication 24 June 2010, doi:10.1042/BJ20100701
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Functional characterization of leucine-specific domain 1 from eukaryal and archaeal leucyl-tRNA synthetases
X.‑Long Zhou, M. Wang, M. Tan, Q. Huang, G. Eriani and E.‑Duo Wang
(2010) 429, 505‑513
Published as BJ Immediate Publication 19 May 2010, doi:10.1042/BJ20100235
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A novel EP-involved pathway for iron release from soya bean seed ferritin
X. Fu, Jianjun Deng, H. Yang, T. Masuda, F. Goto, T. Yoshihara and G. Zhao
(2010) 427, 313‑321
Published as BJ Immediate Publication 10 February 2010, doi:10.1042/BJ20100015
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A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway
C. Li, H. Chen, F. Ding, Y. Zhang, A. Luo, M. Wang and Z. Liu
(2009) 422, 363‑372
Published as BJ Immediate Publication 17 June 2009, doi:10.1042/BJ20090465
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The author has paid for access to this article to be freely availableGDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation
Y. Chen, Y. Deng, J. Zhang, L. Yang, X. Xie and T. Xu
(2009) 422, 229‑235
Published as BJ Immediate Publication 2 July 2009, doi:10.1042/BJ20090624
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Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein
S. Liao, Q. Shang, X. Zhang, J. Zhang, C. Xu and X. Tu
(2009) 422, 207‑215
Published as BJ Immediate Publication 7 July 2009, doi:10.1042/BJ20090738
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A cotton kinesin GhKCH2 interacts with both microtubules and microfilaments
T. Xu, Z. Qu, X. Yang, X. Qin, J. Xiong, Y. Wang, D. Ren and G. Liu
(2009) 421, 171‑180
Published as BJ Immediate Publication 6 May 2009, doi:10.1042/BJ20082020
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Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans
P. Zhang, J. Ma, Z. Zhang, M. Zha, H. Xu, G. Zhao and J. Ding
(2009) 421, 133‑143
Published as BJ Immediate Publication 7 April 2009, doi:10.1042/BJ20090336
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RNA helicase A acts as a bridging factor linking nuclear β-actin with RNA polymerase II
W. Tang, W. You, F. Shi, T. Qi, L. Wang, Z. Djouder, W. Liu and X. Zeng
(2009) 420, 421–428
Published as BJ Immediate Publication 23 March 2009, doi:10.1042/BJ20090402
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Peptide mimics of a conserved H5N1 avian influenza virus neutralization site
W. Luo, Y. Chen, M. Wang, Y. Chen, Z. Zheng, H. Song, H. Chen, Y. Guan, M.H. Ng, J. Zhang and N. Xia
(2009) 419, 133–139
Published as BJ Immediate Publication 30 October 2008, doi:10.1042/BJ20080083
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Solution structure and catalytic mechanism of human protein histidine phosphatase 1
W. Gong, Y. Li, G. Cui, J. Hu, H. Fang, C. Jin and B. Xia
(2009) 418, 337–344
Published as BJ Immediate Publication 7 November 2008, doi:10.1042/BJ20081571
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Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia
C.-P. Du, J. Gao, J.-M. Tai, Y. Liu, J. Qi, W. Wang and X.-Y. Hou
(2009) 417, 277–285
Published as BJ Immediate Publication 22 August 2008, doi:10.1042/BJ20080004
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Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts
S. Feng, L. Deng, W. Chen, J. Shao, G. Xu and Y.-P. Li
(2009) 417, 195–203
Published on the Internet 12 December 2008, doi:10.1042/BJ20081073
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Human D-Tyr-tRNATyr deacylase contributes to the resistance of the cell to D-amino acids
G. Zheng, W. Liu, Y. Gong, H. Yang, B. Yin, J. Zhu, Y. Xie, X. Peng, B. Qiang and J. Yuan
(2009) 417, 85–94
Published as BJ Immediate Publication 14 August 2008, doi:10.1042/BJ20080617
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Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys10 and His106
X.-Y. Wang, Z.-R. Zhang and S. Perrett
(2009) 417, 55–64
Published as BJ Immediate Publication 9 September 2008, doi:10.1042/BJ20071702
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Down-regulation of hepatic nuclear factor 4α on expression of human hepatic stimulator substance via its action on the proximal promoter in HepG2 cells
D. Guo, L.-y. Dong, Y. Wu, L. Yang and W. An
(2008) 415, 111–121
Published as BJ Immediate Publication 2 June 2008, doi:10.1042/BJ20080221
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Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
J. Ma, P. Zhang, Z. Zhang, M. Zha, H. Xu, G. Zhao and J. Ding
(2008) 415, 45–56
Published as BJ Immediate Publication 23 May 2008, doi:10.1042/BJ20080242
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Characterization of the topology and functional domains of RKTG
X. Luo, L. Feng, X. Jiang, F. Xiao, Z. Wang, G.-S. Feng and Y. Chen
(2008) 414, 399–406
Published as BJ Immediate Publication 11 June 2008, doi:10.1042/BJ20080948
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The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell-cycle arrest in T-cells
Y. Zhang, Z. Yang, Y. Cao, S. Zhang, H. Li, Y. Huang, Y.-q. Ding and X. Liu
(2008) 413, 239–250
Published as BJ Immediate Publication 31 March 2008; doi:10.1042/BJ20071510
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Conserved amphiphilic feature is essential for periplasmic chaperone HdeA to support acid resistance in enteric bacteria
Y.E. Wu, W. Hong, C. Liu, L. Zhang and Z. Chang
(2008) 412, 389–397
Published as BJ Immediate Publication 14 February 2008, doi:10.1042/BJ20071682
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Involvement of Egr-1 in HGF-induced elevation of the human 5a-R1 gene in human hepatocellular carcinoma cells
C. Rui, C. Li, W. Xu, Y. Zhan, Y. Li and X. Yang
(2008) 411, 379–386
Published as BJ Immediate Publication 14 January 2008, doi:10.1042/BJ20071343
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The dramatically increased chaperone activity of small heat-shock protein IbpB is retained for an extended period of time after the stress condition is removed
W. Jiao, W. Hong, P. Li, S. Sun, J. Ma, M. Qian, M. Hu and Z. Chang
(2008) 410, 63–70
Published as BJ Immediate Publication 12 November 2007, doi:10.1042/BJ20071120
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Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast
Q. Han, J. Lu, J. Duan, D. Su, X. Hou, F. Li, X. Wang and B. Huang
(2008) 409, 779–788
Published as BJ Immediate Publication 2 October 2007, doi:10.1042/BJ20070578
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Human heart LIM protein activates atrial-natriuretic-factor gene expression by interacting with the cardiac-restricted transcription factor Nkx2.5
B. Zheng, M. Han, J.-k. Wen and R. Zhang
(2008) 409, 683–690
Published as BJ Immediate Publication 11 October 2007, doi:10.1042/BJ20070977
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The essential role for c-Ski in mediating TGF-β1-induced bi-directional effects on skin fibroblast proliferation through a feedback loop
X. Liu, P. Li, P. Liu, R. Xiong, E. Zhang, X. Chen, D. Gu, Y. Zhao, Z. Wang and Y. Zhou
(2008) 409, 289–297
Published as BJ Immediate Publication 28 August 2007, doi:10.1042/BJ20070545
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Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway
S.C. Chan, S.-C. Lin and P. Li
(2007) 408, 259–266
Published as BJ Immediate Publication 22 August 2007, doi:10.1042/BJ20070690
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Identification and characterization of two closely related histone H4 arginine 3 methyltransferases in Arabidopsis thaliana
D. Yan, Y. Zhang, L. Niu, Y. Yuan and X. Cao
(2007) 408, 113–121
Published as BJ Immediate Publication 1 August 2007, doi:10.1042/BJ20070786
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Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor kB transcriptional activation in neuroblastoma SH-SY5Y cells
X. Lin, Q. Li, Y.-J. Wang, Y.-W. Ju, Z.-Q. Chi, M.-W. Wang and J.-G. Liu
(2007) 406, 215–221
Published as BJ Immediate Publication 4 June 2007, doi:10.1042/BJ20070186
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Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a
B. Li, J. Zhou, P. Liu, J. Hu, H. Jin, Y. Shimono, M. Takahashi and G. Xu
(2007) 405, 369–378
Published as BJ Immediate Publication 18 April 2007, doi:10.1042/BJ20061873
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Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site
S. Li, Y. Lu, B. Peng and J. Ding
(2007) 401, 39–47
Published as BJ Immediate Publication 30 August 2006, doi:10.1042/BJ20061066
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Recruitment of histone deacetylase 4 by transcription factors represses interleukin-5 transcription
S. Han, J. Lu, Y. Zhang, C. Cheng, L. Han, X. Wang, L. Li, C. Liu and B. Huang
(2006) 400, 439–448
Published as BJ Immediate Publication 22 August 2006, doi:10.1042/BJ20061085
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Crystal structure of the SENP1 mutant C603S–SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease
Z. Xu, S.F. Chau, K.H. Lam, H.Y. Chan, T.B. Ng and S.W.N. Au
(2006) 398, 345–352
Published as BJ Immediate Publication 22 May 2006, doi:10.1042/BJ20060526
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Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Y. Liu, J. Liao, B. Zhu, E.-D. Wang and J. Ding
(2006) 394, 399–407
Published as BJ Immediate Publication 8 November 2005, doi:10.1042/BJ20051249
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